Everything must follow the physical laws of nature, and if the physics of the process can be calculated (for example heat transfer) then you can simulate the process. There are certain things which are so complex or so far from a physical process (a person painting a picture for example) that it is truly an art. However I have even seen computer programs than can emulate the painting process, although true creativity is not emulated.
By developing models our understanding of the process is greatly increased. Some models have inaccuracies, and studying the inaccuracies helps to improve the model even more.
I work with and sell modeling software every day and use it mostly for screw design. I got into simulation after 20 years of hands-on working with the process. Modeling helped to explain things that happened that I could not previously explain. Even after another 10+ years of working on screw design with simulation I'm still amazed at what I am learning.
For the engineer that is afraid that his "art" or his job will be replaced by simulation software, it is just not true. I don't believe it has ever happened. Nobody wants your job; it is just too difficult with or without software. It takes a brave soul to tackle these complex processes, and most people are smart enough to walk away. (Took me a while to figure out why nobody wanted to do screw design, while I found it interesting.)
Like it or not; if you work on a process you make calculations, use models, and do simulations in your mind. It is just a matter of how complex a calculator do you want to use. Not all plastic processes have been attempted to be modeled, or successfully modeled, but we continue to learn.
B-Sim is an available blow molding simulation package.
http://compuplast.ca/BSim.htmB-Sim only covers part of the process. Melt making, distribution, filling, extrusion can be covered by other modeling packages.